How long is Alfaxan good for?
SUMMARY. Alfaxalone has been used to induce general anesthesia for many years, but only recently has a new formulation with preservatives become available in the United States. This formulation has a shelf life of 28 days after first use.
How long is Alfaxan multidose good for once opened?
ALFAXAN MULTIDOSE IDX contains preservatives. Use within 56 days of first puncture. Any unused ALFAXAN MULTIDOSE IDX remaining after 56 days should be discarded. The following tables outline the dosage and administration of ALFAXAN MULTIDOSE IDX for the indicated species by major group.
What is the difference between Alfaxan and Alfaxan multidose?
Alfaxan Multidose is bioequivalent to unpreserved Alfaxan, however the preserved system reduces risk of microbial contamination, prolonging the shelf life after the first use to 28 days.
Where is alfaxalone metabolized?
Alfaxalone is remarketed as a water-soluble neuroanaesthetic. Water solubility was achieved by binding the alfaxalone-molecule to a cyclodextrine molecule. It is rapidly metabolized by the liver and does not cause histamine release like the former formulation.
Is alfaxalone safe?
Alfaxalone is safe and effective at 12–15 mg/kg IM for routine noninvasive procedures and lasts approximately 40–45 min [15,16]. The most common side effects are dose-dependent but transient hypotension (15 min), hypoventilation, and apnea.
Is alfaxalone safe for cats?
Alfaxalone is a neuroactive steroid that is approved for use as an injectable anesthetic agent in dogs and cats.
Can you reverse alfaxalone?
There is no reversal agent for alfaxalone; however, other drugs administered that cause cardiorespiratory depression should be antagonised if possible.
What is Alfaxan multidose?
ALFAXAN MULTIDOSE (alfaxalone) is a neuroactive steroid molecule with properties of a general anesthetic. Alfaxalone is chemically described as 3-α-hydroxy-5-α-pregnane-11, 20-dione, and has a molecular weight 332.5.
Is alfaxalone controlled?
Alfaxalone is classified by the Drug Enforcement Agency as a Schedule IV controlled substance. More information: Issued by FDA Center for Veterinary Medicine.
What is Alfaxan used for?
Alfaxalone, also known as alphaxolone or alphaxalone and used under the trade name Alfaxan®, is a neuroactive steroid and general anesthetic drug used in dogs and cats. It can be used as an induction agent or for general anesthesia. Although expensive, it has some important advantages.
How is Alfaxan metabolised?
The pharmacokinetics of Alfaxan Multidose After a single dose of Alfaxan Multidose, alfaxalone is metabolized rapidly in the liver and eliminated in the bile and urine, with the drug being completely cleared from the body within a few hours after administration.
Is alfaxalone a steroid?
Alfaxalone is a neuroactive steroid that is approved for use as an injectable anesthetic agent in dogs and cats. Alfaxalone can be used for sedation, induction of anesthesia, and for total intravenous anesthesia (TIVA).
