What is Basigin malaria?
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum .
What is the deadliest Plasmodium?
Plasmodium falciparum is the most deadly of the human malaria parasites.
What disease does Plasmodium falciparum cause?
Plasmodium falciparum is the type of malaria that most often causes severe and life-threatening malaria; this parasite is very common in many countries in Africa south of the Sahara desert. People who are heavily exposed to the bites of mosquitoes infected with P. falciparum are most at risk of dying from malaria.
What are the 5 types of Plasmodium that causes malaria?
Five species of Plasmodium (single-celled parasites) can infect humans and cause illness:
- Plasmodium falciparum (or P. falciparum)
- Plasmodium malariae (or P. malariae)
- Plasmodium vivax (or P. vivax)
- Plasmodium ovale (or P. ovale)
- Plasmodium knowlesi (or P. knowlesi)
Where is CD147 located?
The CD147 coding region encodes 269 amino acid residues, including two C2-type immunoglobulin regions in the extracellular N-terminal sequence [27], 24 amino acid residues located in the transmembrane region and 39 amino acid residues in the C-terminal intracellular region [25].
Is Plasmodium falciparum a bacteria?
Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease’s most dangerous form, falciparum malaria.
Why is falciparum malaria more severe?
falciparum infection due to intense hemolysis (destruction) of infected RBCs due to higher parasitemia caused by the parasite. Unlike other Plasmodium species, P. falciparum infect all types of RBCs found at different stages of development (from immature young to old RBCs).
What are the complications of Plasmodium falciparum infection?
The Plasmodium falciparum parasite causes the most severe malaria symptoms and most deaths….Malaria in pregnancy
- premature birth – birth before 37 weeks of pregnancy.
- low birth weight.
- restricted growth of the baby in the womb.
- stillbirth.
- miscarriage.
- death of the mother.
Is falciparum malaria curable?
In general, it takes about two weeks of treatment to be cured of malaria. However, in some individuals, relapses are possible. The time period from initial parasite infection to the appearance of symptoms varies according to the particular species of Plasmodium that infects an individual.
How is falciparum malaria treated?
Approved therapies for treatment of uncomplicated falciparum malaria in the United States include atovaquone–proguanil, quinine (a 3-day course plus a 1-week course of doxycycline or, in children, clindamycin), and mefloquine.
What is the life cycle of malarial parasite?
The malaria parasite life cycle involves two hosts During a blood meal, a malaria-infected female Anopheles mosquito injects sporozoites into the human host, following which sporozoites infect liver cells and mature into schizonts to release merozoites.
Is Plasmodium a bacteria or virus?
A: Malaria is not caused by a virus or bacteria. Malaria is caused by a parasite known as Plasmodium, which is normally spread through infected mosquitoes. A mosquito takes a blood meal from an infected human, taking in Plasmodia which are in the blood.
How does Plasmodium falciparum invade the erythrocyte?
Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion requires a series of extracellular recognition events between erythrocyte receptors and ligands on the merozoite, the invasive form of the parasite.
Is Basigin a receptor for a parasite ligand?
By systematically screening a library of erythrocyte proteins, we have found that the Ok blood group antigen, basigin, is a receptor for PfRh5, a parasite ligand that is essential for blood stage growth 6.
Is Basigin an immunoglobulin?
Basigin is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family.
Is there a second form of basigin?
A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. Basigin has been shown to interact with Ubiquitin C. Basigin has been shown to form a complex with monocarboxylate transporters in the retina of mice.
